Nicotinic acetylcholine receptors containing α9 subunits (α9*-nAChRs) are potential
druggable targets arousing great interest for pain treatment alternative to opioids …

A series of azaaromatic quaternary ammonium analogs has been discovered as potent and
selective α9α10 nicotinic acetylcholine receptor (nAChR) antagonists. The preliminary …

Modifications of the cationic head and the ethylene linker of 2-(triethylammonium) ethyl ether
of 4-stilbenol (MG624) have been proved to produce selective α9*-nAChR antagonism …

Abstract The α9-and α7-containing nicotinic acetylcholine receptors (nAChRs) mediate
numerous physiological and pathological processes by complex mechanisms that are …

There is an urgent need for nonopioid treatments for chronic and neuropathic pain to
provide effective alternatives amid the escalating opioid crisis. This study introduces novel …

A series of 2-(arylmethyl)-3-substituted quinuclidines was developed as α7 neuronal
nicotinic acetylcholine receptor (nAChR) agonists based on a putative pharmacophore …

Efforts in the design and discovery of selective α7 nicotinic acetylcholine receptor (nAChR)
agonists were both facilitated and hampered by observation that ligands can show dual …

To better understand the effects of weak as well as strong agonists at the human α7 nicotinic
acetylcholine receptor (human α7 nAChR), the abilities of several classic nAChR agonists to …

A series of ligands based on SEN12333, containing either contracted or elongated alkyl
chains, were synthesized and evaluated in molecular docking studies against a homology …

We introduce the term 'silent agonists' to describe ligands that can place the α7 nicotinic
acetylcholine receptor (nAChR) into a desensitized state with little or no apparent activation …