Immunity and cytokines serve crucial roles in cutaneous melanoma. The present study
investigated whether a variable number tandem repeat (VNTR) polymorphism of interleukin …

Genetic variation in immune-regulating components such as cytokines may lead to
interindividual differences in immunosuppression response and susceptibility to melanoma …

Cutaneous melanoma is the most aggressive skin cancer with high mortality.
Proinflammatory cytokines can modulate the proliferation and survival of cutaneous …

Cutaneous malignant melanoma (CMM) is a potentially fatal malignancy in which exposure
to UV light is the most important risk factor. Several lines of evidence suggest that CMM …

Cutaneous malignant melanoma (CMM) is one of the most immunogenic types of cancer,
with a 6‑fold higher rate of spontaneous regression than any other malignancy. In addition to …

The immune response against melanoma can be influenced by cytokines with potentially
opposite effects on tumour cell growth, such as interleukin-10 (IL10), interleukin-6 (IL6) and …

Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10
production may contribute to a genetic susceptibility for melanoma. We investigated the role …

OBJECTIVE: The interleukin-1 receptor antagonist (IL-1RA) contributes to tumor survival and
progression in multiple cancer entities. IL-1RA polymorphisms influence IL-1RA expression …

Melanoma is an immunogenic tumor; however, the efficacy of immune-therapy shows large
inter-individual variation with possible influence of background genetic variation. In this …

Inherited genetic factors may modulate clinical outcome in melanoma. Some low‐to‐
medium risk genes in melanoma susceptibility play a role in melanoma outcome. Our aim …