The use of efflux pump inhibitors (EPIs) as potentiators along with the traditional antibiotics
assists in the warfare against antibiotic-resistant superbugs. Efflux pumps of the resistance …

Abstract Resistance–nodulation–division (RND) superfamily efflux pumps play a major role
in multidrug resistance (MDR) of Gram-negative pathogens by extruding diverse classes of …

Infectious diseases remain one of the principal causes of morbidity and mortality in the
world. Relevant authorities including the WHO and CDC have expressed serious concern …

Multidrug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae
and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat …

Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic
resistance in many bacterial pathogens, representing candidate targets for the development …

Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the
morbidity and mortality of hospitalized patients. The rise of resistance to current antibiotic …

Members of the resistance-nodulation-division (RND) family of efflux pumps, such as AcrAB-
TolC of Escherichia coli, play major roles in multidrug resistance (MDR) in Gram-negative …

Highlights•Efflux pumps play a major role in multidrug resistance (MDR) in bacteria.•RND
family efflux pumps are the major MDR pumps in the Gram-negative pathogens.•Efflux pump …

Efflux, particularly that mediated by the resistance-nodulation-division (RND) family of
multiple antibiotic efflux systems that are prevalent in Gram-negative pathogenic bacteria, is …