Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …

Chronic exposure to drugs of abuse is linked to long-lasting alterations in the function of
limbic system structures, including the nucleus accumbens (NAc). Although cocaine acts via …

Although dopamine is implicated in the development of addiction, it is unclear how specific
dopamine release patterns are involved with drug seeking. Addictive drugs increase tonic …

Using a model of recreational cocaine consumption, we have determined in four rhesus
monkeys the impact of self-administered cocaine on mesolimbic and sensorimotor striatal …

Background Prominent neurobiological theories of addiction posit a central role for aberrant
mesolimbic dopamine release but disagree as to whether repeated drug experience blunts …

Abuse of psychoactive substances can lead to drug addiction. In animals, addiction is best
modeled by drug self-administration paradigms. It has been proposed that the crucial …

Drug addiction is characterized by motivational disturbances such as compulsive drug
taking and episodes of intense drug craving. Recent advances using animal models of …

The involvement of dopamine in drug reinforcement is well recognized but its role in drug
addiction is much less clear. Imaging studies have shown that the reinforcing effects of drugs …

Despite large numbers of studies describing neuroadaptations caused by chronic cocaine
exposure, there remains considerable uncertainty as to whether alterations in dopamine …

Drug addiction is characterized by a set of recurring processes (intoxication, withdrawal,
craving) that lead to the relapsing nature of the disorder. We have used positron emission …