Chemoresistance is a serious limitation of cancer treatment. Until recently, almost all the
work done to study this limitation has been restricted to tumour cells. Here we identify a …

The nonreceptor protein tyrosine kinase, focal adhesion kinase (FAK, also known as PTK2),
is a key mediator of signal transduction downstream of integrins and growth factor receptors …

Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological
angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce …

Purpose: Non–small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths
worldwide due to the limited availability of effective therapeutic options. For instance, there …

Focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase and scaffold protein localized to
focal adhesions, is uniquely positioned at the convergence point of integrin and receptor …

Focal adhesion kinase (FAK) promotes anti-tumor immune evasion. Specifically, the kinase
activity of nuclear-targeted FAK in squamous cell carcinoma (SCC) cells drives exhaustion …

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays a fundamental role
in integrin and growth factor mediated signalling and is an important player in cell migration …

It is twenty years since Focal Adhesion Kinase (FAK) was found to be overexpressed in
many types of human cancer. FAK plays an important role in adhesion, spreading, motility …

Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and
metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular …

Focal adhesion kinase (FAK), a nonreceptor protein tyrosine kinase, is frequently
overexpressed in various tumors and its expression shows good correlation with the …