NK cells are known to respond in vitro to P. falciparum-infected red blood cells (iRBCs),
although responses are highly heterogeneous between donors. Although their role during …

Malaria is a one of the major life-threatening infections worldwide causing thousands of
deaths every year. Natural killer cells are thought to play a role in innate responses against …

Human adaptive natural killer (NK) cells have diminished reliance on accessory cytokines
for their activation whilst being efficiently activated by infected host cells in conjunction with …

Human NK cells can respond rapidly to Plasmodium falciparum-infected RBC (iRBC) to
produce IFN-γ. In this study, we have examined the heterogeneity of this response among …

Human NK cells are the earliest source of the protective cytokine IFN-γ when PBMC from
nonimmune donors are exposed to Plasmodium falciparum-infected RBC (iRBC) in vitro. In …

Killer-cell immunoglobulin-like receptors (KIRs) are a group of natural killer cell receptors
(NKRs) that regulate NK-cell-mediated production of interferon gamma (IFN-γ) in response …

The biology of Natural Killer (NK) cells and other NK Receptor (NKR)+ leukocytes has
largely been elucidated in viral or cancer systems, and involvement in other diseases or …

To determine the potential contribution of innate immune responses to the early
proinflammatory cytokine response to Plasmodium falciparum malaria, we have examined …

Data from a variety of experimental models suggest that natural killer (NK) cells require
signals from accessory cells in order to respond optimally to pathogens, but the precise …

Plasmodium falciparum (Pf) infection is a major cause of morbidity and mortality world-wide
where symptoms and death occur as a result of the blood stage of the Pf life cycle. To date …