Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats
Y Ren, J Jiang, W Jiang, X Zhou, W Lu, J Wang… - Neurochemical …, 2021 - Springer
Brain inflammation induced by ischemic stroke is an important cause of secondary brain
injury. The nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and …
injury. The nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and …
PHLDA1 blockade alleviates cerebral ischemia/reperfusion injury by affecting microglial M1/M2 polarization and NLRP3 inflammasome activation
H Zhao, Y Liu, N Chen, H Yu, S Liu, M Qian, Z Zhang - Neuroscience, 2022 - Elsevier
Cerebral ischemia/reperfusion injury is the main cause of neurological deficit following
stroke. Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is increasingly …
stroke. Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is increasingly …
Regulation of microglia-activation-mediated neuroinflammation to Ameliorate Ischemia-reperfusion injury via the STAT5-NF-κB pathway in ischemic stroke
Z Pu, S Xia, P Shao, X Bao, D Wu, Y Xu - Brain sciences, 2022 - mdpi.com
Inflammatory reaction after ischemia-reperfusion contributes significantly to a worsened
prognosis, and microglia activation is the main resource of inflammation in the nervous …
prognosis, and microglia activation is the main resource of inflammation in the nervous …
Modified citrus pectin alleviates cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome activation via TLR4/NF-ĸB signaling pathway in microglia
Y Cui, NN Zhang, D Wang, WH Meng… - Journal of Inflammation …, 2022 - Taylor & Francis
Background Galectin-3 acts as a mediator of microglial inflammatory response following
stroke injury. However, it remains unclear whether inhibiting galectin-3 protects against …
stroke injury. However, it remains unclear whether inhibiting galectin-3 protects against …
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
S Zheng, Y Li, X Song, M Wu, L Yu, G Huang… - Journal of …, 2023 - Springer
Background Inflammatory response triggered by innate immunity plays a pivotal element in
the progress of ischemic stroke. Receptor-interacting kinase 2 (RIP2) is implicated in …
the progress of ischemic stroke. Receptor-interacting kinase 2 (RIP2) is implicated in …
Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after MCAO in rats
G Wu, DW McBride, JH Zhang - Neurobiology of disease, 2018 - Elsevier
Background and purpose Ischemic stroke activates Toll-like receptors (TLRs), triggering
rapid inflammatory cytokine production. Axl signaling has multiple roles, including regulating …
rapid inflammatory cytokine production. Axl signaling has multiple roles, including regulating …
PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia
L Peng, Y Ji, Y Li, Y You, Y Zhou - Cell Communication and Signaling, 2024 - Springer
The crosstalk between astrocytes and microglia plays a pivotal role in neuroinflammation
following ischemic stroke, and phenotypic distribution of these cells can change with the …
following ischemic stroke, and phenotypic distribution of these cells can change with the …
[HTML][HTML] HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway
Y Liao, J Cheng, X Kong, S Li, X Li, M Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: It is known that neuroinflammation plays a critical and detrimental role in the
development of cerebral ischemia/reperfusion (I/R), but the regulation of the cyclic GMP …
development of cerebral ischemia/reperfusion (I/R), but the regulation of the cyclic GMP …
Rab7b overexpression–ameliorated ischemic brain damage following tMCAO involves suppression of TLR4 and NF-κB p65
J Qi, Y Rong, L Wang, J Xu, K Zhao - Journal of Molecular Neuroscience, 2019 - Springer
Cerebral stroke is one of the leading causes of death and permanent disability worldwide.
Toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) p65 play a critical role in …
Toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) p65 play a critical role in …
Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway
Y Ran, S Qie, F Gao, Z Ding, S Yang, G Tian, Z Liu, J Xi - Brain research, 2021 - Elsevier
Microglial polarization mediated neuroinflammation plays an important role in the
pathological process of stroke. The aim of this study is to determine whether baicalein …
pathological process of stroke. The aim of this study is to determine whether baicalein …
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