Evidence of aberrant renal microvascular architecture in various forms of renal disease
provides the impetus to attempt modulating the renal microcirculation to interfere with the …

Emerging evidence supports the pivotal role of renal microvascular disease as a
determinant of tubulo-interstitial and glomerular fibrosis in chronic kidney disease. An intact …

Chronic kidney disease is characterized by progressive loss of the renal microvasculature,
which leads to local areas of hypoxia and induction of profibrotic responses, scarring and …

The role of the vascular endothelium in progressive renal disease is not well understood.
This review presents evidence that progressive renal disease is characterized by a …

Background Renal artery stenosis (RAS) is an important cause of chronic kidney disease
and secondary hypertension. In animal models, renal ischemia leads to downregulation of …

Experimental and clinical studies suggest that the damage of the renal microvascular
function and architecture may participate in the early steps of renal injury in chronic renal …

Kidneys are highly vascular organs that despite their relatively small size receive 20% of the
cardiac output. The highly intricate, delicately organized structure of renal microcirculation is …

Chronic kidney disease (CKD) affects 8–16% of the population worldwide and is
characterized by fibrotic processes. Understanding the cellular and molecular mechanisms …

The renal microvasculature is emerging as a key player in acute and chronic kidney
diseases. Renal microvascular disease involves alterations in endothelial barrier …

The renal microvasculature is composed of the glomerular and peritubular capillary beds
which supply the cellular constituents of the kidney with oxygen and nutrients as well as …