Natural products are historically one of the most important pharmaceutical sources for drug
development. In the post-genomic era, next generation sequencing analyses of …

Natural products are historically one of the most important pharmaceutical sources for drug
development. In the post-genomic era, next generation sequencing analyses of …

A synthetic biology method based on heterologous biosynthesis coupled with genome
mining is a promising approach for increasing the opportunities to rationally access natural …

Covering: up to 2014 Large scale fungal genome sequencing has revealed a multitude of
potential natural product biosynthetic pathways that remain uncharted. Here we describe …

Highlights•Fungi are an excellent source of drugs, and their full potential in producing
different metabolites is still largely untapped.•Several heterologous platforms have been …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Natural products play important roles not only in the environment but also as useful
compounds in various applications like in medicine or plant protection. An enormous …

Genome mining has been proven invaluable for discovering natural products, yet a
significant challenge remains in selectively extracting biosynthetic gene clusters (BGCs) for …

Fungal natural products include antibiotics such as the penicillins, antirejection drugs such
as cyclosporins and cholesterollowering drugs such as the statins. High productivity of these …

In nature, organic molecules with great structural diversity and complexity are synthesized
by utilizing a relatively small number of starting materials. A synthetic strategy adopted by …