Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

AS Al‐Shami, AE Essawy… - Phytotherapy …, 2023 - Wiley Online Library
Neurodegenerative disorders are heterogeneous, debilitating, and incurable groups of brain
disorders that have common features including progressive degeneration of the structure …

The phytoestrogenic isoflavones from Trifolium pratense L.(Red clover) protects human cortical neurons from glutamate toxicity

F Occhiuto, G Zangla, S Samperi, DR Palumbo, A Pino… - Phytomedicine, 2008 - Elsevier
The endogenous steroid estrogen has been shown to affect neuronal growth, differentiation
and survival. Genistein, daidzein and other isoflavones have been shown to mimic the …

Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen

L Singh, H Kaur, G Chandra Arya… - Chemical Biology & …, 2024 - Wiley Online Library
The increased prevalence of neurological illnesses is a burgeoning challenge to the public
healthcare system and presents greater financial pressure. Formononetin, an O‐methylated …

The isoflavones mixture from Trifolium pratense L. protects HCN 1‐A neurons from oxidative stress

F Occhiuto, DR Palumbo, S Samperi… - … Journal Devoted to …, 2009 - Wiley Online Library
Oxidative stress‐induced neuronal cell death has been implicated in different neurological
disorders and neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: evidence from preclinical studies

Y Ren, S Qu - Ageing research reviews, 2023 - Elsevier
With the increasing aging population worldwide, the incidence of senile cognitive
impairment (CI) is increasing, posing a serious threat to the health of elderly persons …

Synergistic action of flavonoids, baicalein, and daidzein in estrogenic and neuroprotective effects: a development of potential health products and therapeutic drugs …

RCY Choi, JTT Zhu, AWY Yung… - Evidence‐Based …, 2013 - Wiley Online Library
Despite the classical hormonal effect, estrogen has been reported to mediate
neuroprotection in the brain, which leads to the searching of estrogen‐like substances for …

Neuroprotective properties of Betulin, Betulinic acid, and Ursolic acid as triterpenoids derivatives: A comprehensive review of mechanistic studies

M Farzan, M Farzan, M Shahrani, SP Navabi… - Nutritional …, 2024 - Taylor & Francis
Cognitive deficits are the main outcome of neurological disorders whose occurrence has
risen over the past three decades. Although there are some pharmacologic approaches …

Exploring the Therapeutic Potential of Phytoconstituents for Addressing Neurodegenerative Disorders

S Kamboj, P Sharma, R Kamboj… - … System Agents in …, 2024 - ingentaconnect.com
Neurodegenerative disorder is a serious condition that is caused by abnormal or no
neurological function. Neurodegenerative disease is a major growing cause of mortality and …

[HTML][HTML] Molecular targets involved in the neuroprotection mediated by terpenoids

L González-Cofrade, B De Las Heras, LA Ticona… - Planta …, 2019 - thieme-connect.com
Natural products and their derivatives represent the most consistently successful source of
drug leads. Terpenoids, a structurally diverse group, are secondary metabolites widely …

Exploring the anti-neuroinflammatory potential of steroid and terpenoid-derived phytochemicals to combat Alzheimer's disease

MT Kabir, MS Uddin, S Zaman… - Current …, 2021 - ingentaconnect.com
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
significantly affects cognitive functions in a way that causes loss of memory, thinking, and …