The mechanics of the cellular microenvironment continuously modulates cell functions such
as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal …

Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …

The regulation of size, volume and mass in living cells is physiologically important, and
dysregulation of these parameters gives rise to many diseases. Cell mass is largely …

Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the
cytoskeleton or distortion of the cell and organelles, induce metabolic changes in the cell …

Tubular epithelia are a basic building block of organs and a common site of cancer
occurrence,,–. During tumorigenesis, transformed cells overproliferate and epithelial …

Cells can sense the density and distribution of extracellular matrix (ECM) molecules by
means of individual integrin proteins and larger, integrin-containing adhesion complexes …

Mammalian tissues are fuelled by circulating nutrients, including glucose, amino acids, and
various intermediary metabolites. Under aerobic conditions, glucose is generally assumed …

Tissue morphogenesis is orchestrated by cell shape changes. Forces required to power
these changes are generated by non-muscle myosin II (MyoII) motor proteins pulling …

As the concentrations of highly consumed nutrients, particularly glucose, are generally lower
in tumours than in normal tissues,, cancer cells must adapt their metabolism to the tumour …

Mechanical stresses elicit cellular reactions mediated by chemical signals. Defective
responses to forces underlie human medical disorders,,, such as cardiac failure and …