Uncontrolled complement activation can cause or contribute to glomerular injury in multiple
kidney diseases. While complement activation plays a causal role in atypical hemolytic …

Joshua M. Thurman, MD The complement cascade is part of the innate immune system and
provides an important line of defense against invasive pathogens. However, the …

Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

Complement and kidney disease, new insights : Current Opinion in Nephrology and
Hypertension Complement and kidney disease, new insights : Current Opinion in …

Abstract The Complement System is an evolutionarily conserved component of immunity
that plays a key role in host defense against infections and tissue homeostasis. However …

The kidneys are often susceptible to complement activation-associated injury (1). Low serum
complement levels resulting from complement activation are classically observed in kidney …

The complement cascade was first recognized as a downstream effector system of antibody-
mediated cytotoxicity. Consistent with this view, it was discovered in the 1960s that …

Complement is part of the innate immune system and plays a fundamental role in the
clearance of immune complexes and cell debris. The main effector mechanisms of …