Context.—Differentiation of non–small cell carcinoma into histologic types is important
because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a …

BACKGROUND: New developments in the treatment of lung cancer have necessitated the
further histologic and cytologic subtyping of nonsmall cell lung carcinomas. Thyroid …

Context.—The distinction of lung adenocarcinoma from other types of primary lung
malignancies is important clinically. Accurate morphologic classification is often hindered …

BACKGROUND: Immunohistochemistry (IHC) for thyroid transcription factor‐1 (TTF‐1) is
used to confirm the diagnosis of lung adenocarcinoma. Napsin A also has shown positivity …

Differentiation of primary from metastatic adenocarcinoma in the lung can be challenging,
and it demands sensitive and specific biomarkers, especially when the tissue for diagnosis …

Recent advances in the treatment of pulmonary adenocarcinoma have increased the need
for accurate typing of non–small cell carcinomas. Immunohistochemistry for thyroid …

The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung
adenocarcinoma in pleural effusions, and to compare its performance with TTF‐1. Napsin A …

Abstract Thyroid transcription factor 1 (TTF-1) is currently the best immunohistochemical
marker for carcinomas of lung origin. Our aim was to compare napsin A to TTF-1 for …

TTF-1 and napsin A are useful biomarkers for differentiating primary lung adenocarcinoma
from metastatic tumors. Studies have shown, however, that TTF-1 and napsin A also can be …

Context.—Immunohistochemistry is a very valuable and often used tool in the differential
diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful …