Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell
(HSC) homeostasis in the adult bone marrow,. During fetal development, expansion of …

Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

Before the emergence of hematopoietic stem cells (HSCs), lineage-restricted progenitors,
such as erythro-myeloid progenitors (EMPs), are detected in the embryo or in pluripotent …

Haematopoietic stem cells (HSCs) are widely studied by HSC transplantation into immune-
and blood-cell-depleted recipients. Single HSCs can rebuild the system after …

Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …

Hematopoietic stem cells (HSCs) in adult marrow are believed to be derived from fetal liver
precursors. To study cell kinetics involved in long-term hematopoiesis, we studied single …

THEORIES of the development of mammalian hepatic haemopoiesis have polarised around
two viewpoints. One hypothesis suggests that multipotential haemopoietic stem cells (HSC) …

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …