In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Kisspeptins, a family of neuropeptides encoded by the Kiss1 gene that are mainly expressed
in discrete neuronal populations of the hypothalamus, have recently emerged as essential …

The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

The hypothalamic hormone GnRH is a central driver of pituitary gonadotropin secretion,
controlling pulsatile gonadotropin secretion, modulating gonadal steroid feedback, and …

Identification, in late 2003, of inactivating mutations of the G protein-coupled receptor
GPR54 as causative factor for absence of puberty and hypogonadotropic hypogonadism in …

In humans and other mammals, a hallmark of female reproductive function is the capacity to
episodically release fertilizable oocytes under the precise control of a cascade of hormonal …

Kisspeptins, a family of peptides encoded by the KISS1 gene which binds GPR54 (or KISS1
receptor), have recently emerged as essential neuropeptide regulators of key aspects of …

The kisspeptin receptor, Kiss1R, also known as Gpr54, is a G protein-coupled receptor
(GPCR), deorphanized in 2001, when it was recognized as canonical receptor for the Kiss1 …

Kisspeptins, which are products of the Kiss1 gene, and their receptor, GPR54, have
emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) …

Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of
reproductive functions in mammals owing to its involvement in the direct activation of …