Recent studies have shown that NO is a central mediator in diseases associated with
thoracic aortic aneurysm, such as Marfan syndrome. The progressive dilation of the aorta in …

Background and purpose: Aortic complications account for the major mortality in Marfan
syndrome (MFS), a connective tissue disorder caused by mutations in FBN1 encoding …

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until
dissection or rupture, requiring surgical intervention as the only available treatment. Here …

Aims Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the
Fibrillin-1 gene. It is associated with formation of thoracic aortic aneurysms that can …

Background. The leading cause of mortality in patients with Marfan syndrome (MFS) is
thoracic aortic aneurysm and dissection. Notch signaling is essential for vessel …

Marfan syndrome (MFS) is characterized by the formation of ascending aortic aneurysms
resulting from altered assembly of extracellular matrix fibrillin-containing microfibrils and …

About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1
gene, which encodes fibrillin-1, a protein essential for the formation and stabilization of …

Major pathologic changes in the proximal aorta underlie the life-threatening aortic
aneurysms and dissections in Marfan Syndrome; current treatments delay aneurysm …

Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when
surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta …