This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

Protein aggregation is a process in which proteins self-associate into imperfectly ordered
macroscopic entities. Such aggregates are generally classified as either amorphous or …

Protein aggregation into amyloid fibrils is linked to multiple neurodegenerative disorders,
such as Alzheimer's, Parkinson's or Creutzfeldt-Jakob disease. A better understanding of the …

The aggregation of proteins and peptides in the form of stable and highly ordered amyloid
fibrils is most commonly associated with pathological conditions such as Alzheimer's …

The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …

Deposition of amyloid β (Aβ) fibrils has been suggested to play a central role in Alzheimer's
disease. In clarifying the mechanism by which fibrils form and moreover in developing new …

In amyloid related diseases, proteins form fibrillar aggregates with highly ordered β-sheet
structure regardless of their native conformations. Formation of such amyloid fibrils can be …

Amyloid fibrils are elongated, insoluble protein aggregates deposited in vivo in amyloid
diseases, and amyloid‐like fibrils are formed in vitro from soluble proteins. Both of these …

The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

The assembly and misassembly of normally soluble proteins into fibrilar structures is thought
to be a causative agent in a variety of human amyloid and prion diseases. Structural and …