This study examined the association between two specific polymorphisms of the gene
encoding the μ-opioid receptor and treatment outcomes in alcohol-dependent patients who …

Rationale Previous studies have demonstrated an association between genetic
polymorphisms of the μ opioid receptor gene (OPRM1) and response to naltrexone …

Background: Recent research has implicated the endogenous opioid system in the
development of alcohol use disorders. The A118G polymorphism of the OPRM1 gene has …

Previous studies have suggested that the effect of naltrexone in patients with alcohol
dependence may be moderated by genetic factors. In particular, the possession of the G …

Opioidergic neurotransmission and, specifically, the μ opioid receptor have been implicated
in the reinforcing effects of a variety of drugs of abuse. Consequently, the present study …

Context Naltrexone hydrochloride treatment for alcohol dependence works for some
individuals but not for everyone. Asn40Asp, a functional polymorphism of the μ-opioid …

Aim The goal of this systematic review was to identify moderators of naltrexone efficacy in
the treatment of alcohol dependence. Methods We searched P ubmed, CINHAL, E mbase, P …

Background: Pharmacotherapy of alcohol dependence (AD) is at an early stage of
development; currently available medications have limited efficacy. It would be clinically …

The μ opioid receptor is implicated in the reward, tolerance and withdrawal effects of alcohol
and other drugs of abuse. 1, 2 This hypothesis is supported by the effects of alcohol on beta …

Importance Alcohol use disorder is one of the leading causes of disability worldwide. While
effective pharmacological treatments exist, they are efficacious only in certain individuals …