Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex
The molecular mechanisms specifying the dendritic morphology of different neuronal
subtypes are poorly understood. Here we demonstrate that the bHLH transcription factor …
subtypes are poorly understood. Here we demonstrate that the bHLH transcription factor …
Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum
R Hand, F Polleux - Neural development, 2011 - Springer
Background The formation of the mammalian central nervous system requires the
establishment of complex neural circuits between a diverse array of neuronal subtypes …
establishment of complex neural circuits between a diverse array of neuronal subtypes …
[HTML][HTML] A screen for downstream effectors of Neurogenin2 in the embryonic neocortex
Neurogenin (Ngn) 1 and Ngn2 encode basic-helix-loop-helix transcription factors expressed
in the developing neocortex. Like other proneural genes, Ngns participate in the …
in the developing neocortex. Like other proneural genes, Ngns participate in the …
Notch and NGF/p75NTR control dendrite morphology and the balance of excitatory/inhibitory synaptic input to hippocampal neurones through Neurogenin 3
P Salama‐Cohen, MÁ Arévalo… - Journal of …, 2006 - Wiley Online Library
We have previously shown that dendrite morphology of cultured hippocampal neurones is
controlled by Notch receptor activation or binding of nerve growth factor (NGF) to its low …
controlled by Notch receptor activation or binding of nerve growth factor (NGF) to its low …
Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
E Andersson, JB Jensen, M Parmar, F Guillemot… - 2006 - journals.biologists.com
Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype
specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is …
specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is …
Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis
During development of the central nervous system, the transition from progenitor
maintenance to differentiation is directly triggered by a lengthening of the cell cycle that …
maintenance to differentiation is directly triggered by a lengthening of the cell cycle that …
Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation
Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional
activation of targets such as NeuroD, while simultaneously controlling progenitor …
activation of targets such as NeuroD, while simultaneously controlling progenitor …
Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis
The specification and differentiation of dentate gyrus granule neurons in the hippocampus
require temporally and spatially coordinated actions of both intrinsic and extrinsic molecules …
require temporally and spatially coordinated actions of both intrinsic and extrinsic molecules …
Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex
The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …
Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development
M Florio, K Leto, L Muzio, A Tinterri… - …, 2012 - journals.biologists.com
By serving as the sole output of the cerebellar cortex, integrating a myriad of afferent stimuli,
Purkinje cells (PCs) constitute the principal neuron in cerebellar circuits. Several …
Purkinje cells (PCs) constitute the principal neuron in cerebellar circuits. Several …