Mitochondrial dysfunction and oxidative damage represent important pathological
mechanisms of myocardial ischemia-reperfusion injury (MI/RI). Searching for potential …

Cardiovascular disease is the leading cause of death worldwide. Reperfusion therapy is
vital to patient survival after a heart attack but can cause myocardial ischemia/reperfusion …

Myocardial ischemia/reperfusion (I/R) injury is the resultantly pathological heart damage
from the restoration of blood supply through percutaneous coronary intervention. Herein …

The accurate delivery of nanoparticles and organic small molecule drugs remains a serious
challenge in nanoparticle-based tumor therapy. Dual-targeted therapy combining tumor cell …

Atherosclerosis is a major cause of cardiovascular and cerebrovascular diseases that have
high mortality and disability rates. Because of its unclear pathogenic mechanism and …

Chemodynamic therapy (CDT) is well acknowledged as potent reactive oxygen species
(ROS)-mediated anticancer strategy. Especially, the study about labile iron pool (LIP) as …

Sonodynamic therapy (SDT) has attracted much attention since it can break the depth-
penetration barrier of phototriggered therapeutic strategies. However, developing …

The therapeutic effect of photothermal therapy (PTT) and photodynamic therapy (PDT) is
severely limited because of the shallow tissue penetration depth of the first near-infrared …

Drug-free macromolecular therapeutics are promising alternatives to traditional drugs.
Nanomedicines with multiple organelles targeting can potentially increase the efficacy …

Porphyrins and their derivatives are widely used as photosensitizers and sonosensitizers in
tumor treatment. Nevertheless, their poor water solubility and low chemical stability reduce …