Most drugs, with few notable exceptions, such as heparin, exert their effects not within the
plasma compartment but in defined target tissues into which drugs must be distributed from …

Despite the accepted knowledge that the activity of antibiotics depends on the unbound
concentration at the site of infection, current pharmacodynamic analysis mostly relies on …

The success of antimicrobial therapy is determined by complex interactions between an
administered drug, a host, and an infecting agent. In a clinical situation, the complexity of …

The majority of infections occur at sites outside the vascular compartment. Although much of
the complex interaction between antibiotics, bacteria and host defence at the site of the …

The concentrations achieved by a particular antibiotic in serum and tissues can be predicted
from pharmacokinetic data. These predictions must be evaluated in the broader context of …

For the optimization of dosing regimens of anti-infective agents, it is imperative to have a
good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever …

Central nervous system (CNS) infections caused by bacteria with reduced sentivity to
antibacterials are an increasing worldwide challenge. In successfully treating these …

In the past, pharmacokinetic (PK) and pharmacodynamic (PD) assessment of antimicrobial
agents was based mostly on measuring plasma or serum concentrations. More attention has …

Traditional pharmacokinetic data analysis yields an antibiotic concentration-versus-time
curve that is descriptive of drug behavior in plasma or serum (5, 11, 50). Early …

Transcapillary exchange of antibiotics and other small molecules is diffusion driven and
occurs in the capillary beds of the tissues. Small polar molecules are ionized at …