Development of a prognostic model for lung adenocarcinoma polarity‐related genes and analysis of immune landscape

H Xu, W Du, X Jing, J Xie, P Li - Biotechnology and Applied …, 2024 - Wiley Online Library
Despite the progress made in the management of lung adenocarcinoma (LUAD), the overall
prognosis for LUAD individuals remains suboptimal. While the role of cell polarity in tumor …

Identification of Prognostic Genes and Immune Landscape Signatures Based on Tumor Microenvironment in Lung Adenocarcinoma

P Han, Y Fan, Q Liu, J Zhou - Disease Markers, 2022 - Wiley Online Library
Background. Lung adenocarcinoma is the most common lung cancer subtype and accounts
for the highest proportion of cancer‐related deaths. The tumor microenvironment influences …

Integrative Analysis of Single-Cell and Bulk RNA Sequencing Reveals Prognostic Characteristics of Macrophage Polarization-Related Genes in Lung …

K Mi, L Zeng, Y Chen, S Yang - International Journal of General …, 2023 - Taylor & Francis
Background Lung adenocarcinoma (LUAD) is a group of cancers with poor prognosis. The
combination of single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (RNA …

The prognostic and biological importance of chromatin regulation-related genes for lung cancer is examined using bioinformatics and experimentally confirmed

S Ren, H Yu - Pathology-Research and Practice, 2023 - Elsevier
Background The pathogenesis and clinical diagnosis of lung adenocarcinoma (LUAD), a
malignant illness with substantial morbidity and mortality, are still being investigated. Genes …

Establishing a Novel Gene Signature Related to Histone Modifications for Predicting Prognosis in Lung Adenocarcinoma

M Liu, X Yu, S Xu, C Qu - Journal of Oncology, 2022 - Wiley Online Library
Background. Epigenetic modifications have been revealed to play an important role in
tumorigenesis and tumor development. This study aims to analyze the role of histone …

Systematic profiling of immune signatures identifies prognostic predictors in lung adenocarcinoma

S Mao, Y Li, Z Lu, Y Che, J Huang, Y Lei, Y Wang… - Cellular Oncology, 2020 - Springer
Purpose Lung adenocarcinoma (LUAD) is the predominant subtype of lung cancer, with
increasing evidence showing clinical benefits of immunotherapy. However, a lack of …

Identification of lung adenocarcinoma subtypes and a prognostic signature based on activity changes of the hallmark and immunologic gene sets

SK Zhou, DH Zeng, MQ Zhang, MM Chen, YM Liu… - Heliyon, 2024 - cell.com
Background Lung adenocarcinoma (LUAD) has a complex tumor heterogeneity. Our
research attempts to clearness LUAD subtypes and build a reliable prognostic signature …

A novel epithelial-mesenchymal transition-related gene signature for prognosis prediction in patients with lung adenocarcinoma

S Feng, C Huang, L Guo, H Wang, H Liu - Heliyon, 2022 - cell.com
Traditional pathological diagnoses and clinical methods are insufficient to accurately predict
the prognosis of lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) …

Systematic construction and validation of an immune prognostic model for lung adenocarcinoma

C Luo, M Lei, Y Zhang, Q Zhang, L Li… - Journal of Cellular …, 2020 - Wiley Online Library
Lung adenocarcinoma (LUAD), the most common non‐small‐cell lung cancer, is
characterized by a dense lymphocytic infiltrate, which indicates that the immune system …

Establishment and Application of a Prognostic Risk Score Model Based on Characteristics of Different Immunophenotypes for Lung Adenocarcinoma

H Gao, Y Liu, Y Hu, M Ge, J Ding, Q Ye - Frontiers in Genetics, 2022 - frontiersin.org
Objective: Lung adenocarcinoma (LUAD) is a highly heterogeneous tumor. Tumor mutations
and the immune microenvironment play important roles in LUAD development and …