Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality.
Bcl-2 is localized to intracellular sites of oxygen free radical generation including …
Bcl-2 is localized to intracellular sites of oxygen free radical generation including …
BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production
PA Amstad, H Liu, M Ichimiya, IK Berezesky… - Redox …, 2001 - Taylor & Francis
It has been hypothesized that programmed cell death is mediated, in part, through the
formation of free radicals via oxidative pathways. Furthermore, it has been proposed that …
formation of free radicals via oxidative pathways. Furthermore, it has been proposed that …
Redox aspects of Bcl-2 function
DW Voehringer, RE Meyn - Antioxidants and Redox Signaling, 2000 - liebertpub.com
The oncogene Bcl-2 has attracted recent research attention as recognition of the importance
of Bcl-2 control over apoptosis commitment in disease development and clinical response to …
of Bcl-2 control over apoptosis commitment in disease development and clinical response to …
Redox mechanisms of cytoprotection by Bcl-2
AJ Kowaltowski, G Fiskum - Antioxidants & redox signaling, 2005 - liebertpub.com
Bcl-2 is a multifunctional protein that protects against cell death induced by a wide variety of
stimuli. The best characterized antiapoptotic Bcl-2 mechanism of action involves direct …
stimuli. The best characterized antiapoptotic Bcl-2 mechanism of action involves direct …
Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway
I Métrailler-Ruchonnet, A Pagano… - Free Radical Biology …, 2007 - Elsevier
Bcl-2 is an antiapoptotic molecule that prevents oxidative stress damage and cell death. We
investigated the possible protective mechanisms mediated by Bcl-2 during hyperoxia …
investigated the possible protective mechanisms mediated by Bcl-2 during hyperoxia …
Effect of Bcl-2 on oxidant-induced cell death and intracellular Ca2+mobilization
M Ichimiya, SH Chang, H Liu… - … of Physiology-Cell …, 1998 - journals.physiology.org
The mechanism by which Bcl-2 inhibits cell death is unknown. It has been suggested that
Bcl-2 functions as an antioxidant. Because Bcl-2 is localized mainly to the membranes of the …
Bcl-2 functions as an antioxidant. Because Bcl-2 is localized mainly to the membranes of the …
Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome
MH Lee, DH Hyun, KA Marshall, LM Ellerby… - Free Radical Biology …, 2001 - Elsevier
Bcl-2 is a gene family involved in the suppression of apoptosis in response to a wide range
of cellular insults. Multiple papers have suggested a link between Bcl-2 and oxidative …
of cellular insults. Multiple papers have suggested a link between Bcl-2 and oxidative …
Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function
JH Jang, YJ Surh - Biochemical pharmacology, 2003 - Elsevier
A substantial body of data from clinical and laboratory studies indicates that reactive oxygen
intermediates are implicated in the pathogenesis of diverse human diseases, including …
intermediates are implicated in the pathogenesis of diverse human diseases, including …
Bcl-2 family proteins as regulators of oxidative stress
N Susnow, L Zeng, D Margineantu… - Seminars in cancer …, 2009 - Elsevier
The Bcl-2 family of proteins includes pro-and anti-apoptotic factors acting at mitochondrial
and microsomal membranes. An impressive body of published studies, using genetic and …
and microsomal membranes. An impressive body of published studies, using genetic and …
Reactive oxygen species and programmed cell death
MD Jacobson - Trends in biochemical sciences, 1996 - cell.com
Bcl-2 is a proto-oncoprotein with apparently one function—to suppress programmed cell
death (PCD)—yet how it does so remains a mystery. Several authors have proposed that Bcl …
death (PCD)—yet how it does so remains a mystery. Several authors have proposed that Bcl …