Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality.
Bcl-2 is localized to intracellular sites of oxygen free radical generation including …

It has been hypothesized that programmed cell death is mediated, in part, through the
formation of free radicals via oxidative pathways. Furthermore, it has been proposed that …

The oncogene Bcl-2 has attracted recent research attention as recognition of the importance
of Bcl-2 control over apoptosis commitment in disease development and clinical response to …

Bcl-2 is a multifunctional protein that protects against cell death induced by a wide variety of
stimuli. The best characterized antiapoptotic Bcl-2 mechanism of action involves direct …

Bcl-2 is an antiapoptotic molecule that prevents oxidative stress damage and cell death. We
investigated the possible protective mechanisms mediated by Bcl-2 during hyperoxia …

The mechanism by which Bcl-2 inhibits cell death is unknown. It has been suggested that
Bcl-2 functions as an antioxidant. Because Bcl-2 is localized mainly to the membranes of the …

Bcl-2 is a gene family involved in the suppression of apoptosis in response to a wide range
of cellular insults. Multiple papers have suggested a link between Bcl-2 and oxidative …

A substantial body of data from clinical and laboratory studies indicates that reactive oxygen
intermediates are implicated in the pathogenesis of diverse human diseases, including …

The Bcl-2 family of proteins includes pro-and anti-apoptotic factors acting at mitochondrial
and microsomal membranes. An impressive body of published studies, using genetic and …

Bcl-2 is a proto-oncoprotein with apparently one function—to suppress programmed cell
death (PCD)—yet how it does so remains a mystery. Several authors have proposed that Bcl …