Many cancer-associated somatic copy number alterations (SCNAs) are known. Currently,
one of the challenges is to identify the molecular downstream effects of these variants …

Determining how somatic copy number alterations (SCNAs) promote cancer is an important
goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high …

Somatic copy-number alterations (SCNA) are a hallmark of many cancer types, but the
mechanistic basis underlying their genome-wide patterns remains incompletely understood …

Somatic copy number alterations (SCNAs) are a pervasive trait of human cancers that
contributes to tumorigenesis by affecting the dosage of multiple genes at the same time. In …

Copy number alterations (CNAs) can promote tumor progression by altering gene
expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do not …

Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

Due to growing throughput and shrinking cost, massively parallel sequencing is rapidly
becoming an attractive alternative to microarrays for the genome-wide study of gene …

Genomics has provided a detailed structural description of the cancer genome. Identifying
oncogenic drivers that work primarily through dosage changes is a current challenge …