Purpose: Fluorescence molecular imaging, using cancer-targeted near infrared (NIR)
fluorescent probes, offers the promise of accurate tumor delineation during surgeries and …

Purpose: Imaging techniques for highly specific detection of cancer cells in vivo can have
applications ranging from preclinical drug discovery studies to clinical cancer diagnosis and …

Clinical imaging performance using a fluorescent antibody was compared across 3 cancers
to elucidate physical and biologic factors contributing to differential translation of epidermal …

Optical imaging of tissue autofluorescence has the potential to provide rapid label-free
screening and detection of surface tumors for clinical applications, including when combined …

Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancers, which
is associated with metastatic potential and poor prognosis in cancer patients. Therefore …

Fluorescence imaging is currently attracting much interest as a method for intraoperative
tumor detection, but most current tracers lack tumor specificity. Therefore, this technique can …

Although the development of tumor-targeted fluorescent probes is a major area of
investigation, it will be several years before these probes are realized for clinical use. Here …

Background Tumor proliferation often occurs from pathologic receptor upregulation. These
receptors provide unique targets for near-infrared (NIR) probes that have fluorescence …

Purpose: Advances in tumor biology created a foundation for targeted therapy aimed at
inactivation of specific molecular mechanisms responsible for cell malignancy. In this paper …

Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …