Spinal cord injury (SCI) induces a pronounced neuroinflammation driven by activation and
proliferation of resident microglia as well as infiltrating peripheral monocyte-derived …

The role of microglia in spinal cord injury (SCI) remains ambiguous, partially due to the
paucity of efficient methods to discriminate these resident microglia with blood-derived …

The role of microglia in spinal cord injury (SCI) remains poorly understood and is often
confused with the response of macrophages. Here, we use specific transgenic mouse lines …

Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …

Introduction: Macrophage activation is a hallmark of spinal cord injury (SCI) pathology. CNS
macrophages, derived from resident microglia and blood monocytes, are ubiquitous …

Background Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have
shown that different pathways of macrophage activation result in cells with different …

Background Astrogliosis is a common phenomenon after spinal cord injury (SCI). Although
this process exerts positive effects on axonal regeneration, excessive astrogliosis imparts …

Granulocyte colony-stimulating factor (G-CSF) was investigated in the present study to
examine whether it could affect the activation status of microglia under microenvironment of …

Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic
opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of …

Traumatic spinal cord injury (SCI) elicits an acute inflammatory response which comprises
numerous cell populations. It is driven by the immediate response of macrophages and …