Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of
vascular development, the molecular mechanisms underlying Ang-1 function are almost …

Angiopoietin (Ang)-2, a context-dependent agonist/antagonist for the vascular-specific Tie2
receptor, is highly expressed by endothelial cells at sites of normal and pathologic …

Endothelial cells are constantly exposed to high or low shear stress in arteries and veins by
the flowing blood. Angiopoietin‐2 (Ang‐2) is acting as a critical regulator of vessel …

Angiopoietin-1 (Ang1) regulates both vascular quiescence and angiogenesis through the
receptor tyrosine kinase Tie2. We and another group have recently shown that Ang1 and …

Angiopoietin-1 (Ang-1) is a recently described angiogenic protein that activates the
endothelial Tie 2 receptor. Disruption of the Ang-1 gene shows that it has an indispensable …

Angiopoietin-1/Tek signaling is a critical regulator of blood vessel development, with
conventional knockout of angiopoietin-1 or Tek in mice being embryonically lethal due to …

Angiopoietin-1 (Ang1) is a strong apoptosis survival factor for endothelial cells. In this study,
the receptor/second messenger signal transduction pathway for the antiapoptotic effect of …

Objective—Angiopoietin-2 (Ang-2) is a non-signal transducing ligand of the endothelial
receptor tyrosine kinase Tie-2. Ang-2 is produced by endothelial cells and acts as an …

Angiopoietins play important roles in the formation of neovessels and complex vascular
networks. Angiopoietin (Ang)-1 and Ang-2 belong to a family of growth factors that display …

Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. Angiopoietin‐
1 (Ang‐1) is widely expressed in human normal adult tissues and promotes blood vessel …