Through a poorly understood mechanism, tumors respond to radiation by secreting
cytokines capable of inhibiting apoptosis in endothelial cells, thereby diminishing treatment …

We have previously shown that radiation increases HIF-1 activity in tumors, causing
significant radioprotection of the tumor vasculature. The impact that HIF-1 activation has on …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

Recent research has shed new light on the critical role of tissue microvasculature in
regulating the tumor response to radiation and drugs. In this issue of Cancer Cell, Moeller et …

Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor
(HIF-1) creates a microenvironment and cancer cells' intrinsic signaling networks conferring …

Human solid tumors contain hypoxic regions that have considerably lower oxygen tension
than the normal tissues. Hypoxia offers resistance to radiotherapy and anticancer …

Approximately 50% of cancer patients receive radiation treatment, either alone or in
combination with other therapies. Tumor hypoxia has long been associated with resistance …

Failure to achieve complete remission after radiation therapy is a predictor of patient
mortality, and hypoxic cancer cells are more likely to survive radiation therapy. Recent …

Hypoxia is a common feature in tumors associated with an increased resistance of tumor
cells to therapies. In addition to O2 diffusion–limited hypoxia, another form of tumor hypoxia …

Abstract Dewhirst, MW Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and
Oxidative Stress. This Failla Lecture focused on the inter-relationships between tumor …