Versatile oral insulin delivery nanosystems: from materials to nanostructures

M Wang, C Wang, S Ren, J Pan, Y Wang… - International Journal of …, 2022 - mdpi.com
Diabetes is a chronic metabolic disease characterized by lack of insulin in the body leading
to failure of blood glucose regulation. Diabetes patients usually need frequent insulin …

A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery

MC Chen, K Sonaje, KJ Chen, HW Sung - Biomaterials, 2011 - Elsevier
Success in the oral delivery of therapeutic insulin can significantly improve the quality of life
of diabetic patients who must routinely receive injections of this drug. However, oral …

Advances in buccal and oral delivery of insulin

A Elsayed, M Al-Remawi, N Jaber… - International Journal of …, 2023 - Elsevier
Diabetes mellitus is a metabolic endocrine disease characterized by chronic hyperglycemia
with disturbances in metabolic processes, such as those related to carbohydrates, fat, and …

Oral insulin delivery platforms: strategies to address the biological barriers

Y Xiao, Z Tang, J Wang, C Liu, N Kong… - Angewandte Chemie …, 2020 - Wiley Online Library
Diabetes mellitus is a lifelong metabolic disease that requires frequent subcutaneous
injections of insulin. However, this method of administration can be associated with patient …

Nanotechnology in insulin delivery for management of diabetes

F Bahman, K Greish, S Taurin - Pharmaceutical …, 2019 - ingentaconnect.com
Diabetes is a group of diseases characterized by hyperglycemia and originating from the
deficiency or resistance to insulin, or both. Ultimately, the most effective treatment for …

Transition from passive to active targeting of oral insulin nanomedicines: enhancement in bioavailability and glycemic control in diabetes

D Kaklotar, P Agrawal, A Abdulla, RP Singh, Sonali… - …, 2016 - Taylor & Francis
Oral insulin nanomedicines are effective tools for therapy and management of both Type I
and Type II diabetes. This review summarizes the various nanocarriers developed so far in …

Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management

A Abdel‐Moneim, H Ramadan - Drug Development Research, 2022 - Wiley Online Library
Diabetes mellitus is one of the most serious public health problems in the world. Repeated
daily injections of subcutaneous insulin is the standard treatment for patients with type 1 …

Challenges and advances in nanoparticle-based oral insulin delivery

RM Ramesan, CP Sharma - Expert Review of Medical Devices, 2009 - Taylor & Francis
For many decades, rigorous efforts have been made worldwide to develop a successful oral
insulin-delivery system, which still remains an elusive goal. However, over the past few …

Nanoparticle based insulin delivery system: the next generation efficient therapy for Type 1 diabetes

G Sharma, AR Sharma, JS Nam, GPC Doss… - Journal of …, 2015 - Springer
Diabetic cases have increased rapidly in recent years throughout the world. Currently, for
type-1 diabetes mellitus (T1DM), multiple daily insulin (MDI) injections is the most popular …

Oral glucose-and pH-sensitive nanocarriers for simulating insulin release in vivo

L Sun, X Zhang, Z Wu, C Zheng, C Li - Polymer Chemistry, 2014 - pubs.rsc.org
We design novel oral glucose sensitive nanocarriers for simulating insulin release using a
modification of mesoporous silica nanoparticles (MSN) surfaces with a sensitive shell and …