The expression of ULK1, a core protein of autophagy, is closely related to autophagic
activity. Numerous studies have shown that pathological abnormal expression of ULK1 is …

Macroautophagy, the degradation of cytoplasmic content by lysosomal fusion, is an
evolutionary conserved process promoting homeostasis and intracellular defence …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Autophagy is a crucial homeostatic mechanism that mediates the degradation of damaged
or excess intracellular components. Such components are engulfed and sequestered into …

During the last decade, the molecular mechanisms controlling the initiation of (macro-)
autophagy have been extensively studied. Two macromolecular kinase complexes are …

Autophagy, the cell process of self‐digestion, plays a pivotal role in maintaining energy
homoeostasis and protein synthesis. When required, it causes degradation of long‐lived …

The mammalian ULK kinase complex is the most upstream component in the
macroautophagy/autophagy signaling pathway. ULK1 and homolog ULK2, the sole …

Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy
as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine …

Abstract Significance: The Atg1/ULK1 (uncoordinated-51 like kinase 1) protein complex
plays an essential role regulating autophagy in mammalian cells. As autophagy is …

Ulk1 is a key autophagy protein. Here, we tested expression and potential function of Ulk1 in
human gastric cancer. Ulk1 mRNA and protein were significantly elevated in multiple fresh …