Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in …

Fusion genes are hybrid genes that combine parts of two or more original genes. They can
form as a result of chromosomal rearrangements or abnormal transcription, and have been …

Although gene fusions have been recognized as important drivers of cancer for decades,
our understanding of the prevalence and function of gene fusions has been revolutionized …

Chromosomal rearrangements that result in oncogenic gene fusions are clinically important
drivers of many cancer types. Rapid and sensitive methods are therefore needed to detect a …

Gene fusion represents a class of molecular aberrations in cancer and has been exploited
for therapeutic purposes. In this paper we describe TumorFusions, a data portal that …

Gene fusions, like BCR/ABL1 in chronic myelogenous leukemia, have long been recognized
in hematologic and mesenchymal malignancies. The recent finding of gene fusions in …

Background Until recently, chromosomal translocations and fusion genes have been an
underappreciated class of mutations in solid tumors. Next-generation sequencing …

Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …

Cancer genomes contain many aberrant gene fusions—a few that drive disease and many
more that are nonspecific passengers. We developed an algorithm (the concept signature …

Gene fusions are one of the most common genomic alterations in pediatric cancer. Many
fusions encode oncogenic drivers and play important roles in cancer diagnosis, risk …