Physiologically based pharmacokinetic (PBPK) models consist of compartments
representing different tissues. As most models are only verified based on plasma …

Objective Predictions of antimicrobial effects typically rely on plasma-based pharmacokinetic-
pharmacodynamic (PK-PD) targets, ignoring target-site concentrations and potential …

The purpose of this review was to assess the advancement of applications for
physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We …

Tissue-to-plasma water partition coefficients (Kpu's) form an integral part of whole body
physiologically based pharmacokinetic (WBPBPK) models. This research aims to improve …

There are numerous areas of application for which PKPD models are a valuable tool. We
studied dose linearity, bone penetration and drug-drug interactions of antibiotics by PKPD …

Conventional mammillary models are frequently used for pharmacokinetic (PK) analysis
when only blood or plasma data are available. Such models depend on the quality of the …

Abstract Study Objective The aim of this study was to compare the achievement of
therapeutic pharmacokinetic–pharmacodynamic (PK‐PD) exposure targets for beta‐lactam …

Ceftazidime is a widely used β‐lactam antibiotic and almost entirely excreted via glomerular
filtration in kidney. The objective of this analysis was to assess the ability of physiologically …

Pharmacokinetics (PK) is a branch of pharmacology present and of vital importance for the
research and development (R&D) of new drugs, post-market monitoring, and continued …

Objectives Our objective was to develop population pharmacokinetic (PK) models for
ceftazidime and avibactam in the plasma and epithelial lining fluid (ELF) of healthy …