The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …

By definition the CTD consists of the amino acid sequences extending from the largest
subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of …

Unlike all other RNA polymerases, the largest subunit (RPB1) of eukaryotic DNA-dependent
RNA polymerase II (RNAP II) has a C-terminal domain (CTD) comprising tandemly repeated …

Highlights•Cryo-EM structures of unbound and elongating Pol III complete the gallery of
eukaryotic RNA polymerases.•Transition from dimeric Pol I to transcribing Pol I involves …

How does the C-terminal domain (CTD) of RNA polymerase II interact specifically with
multiple targets? A recent paper describing the structure of this domain with a mRNA …

RNA polymerase II-like enzymes carry out transcription of genomes in Eukaryota, Archaea,
and some viruses. They also exhibit fundamental similarity to RNA polymerases from …

In recent years a great deal of biochemical and genetic research has focused on the C-
terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II …

The eukaryotic RNA polymerase II (RNAPII) catalyzes the transcription of all protein
encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII …

The largest subunit of RNA polymerase II contains a C-terminal domain (CTD) that plays key
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …