Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy

Z Chu, J Yang, W Zheng, J Sun, W Wang… - Coordination Chemistry …, 2023 - Elsevier
Due to the rapid proliferation of tumors, the hydrogen peroxide (H 2 O 2) concentration of
tumor cells is higher than that of normal cells, which can be used as an effective target for …

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

Y Sang, F Cao, W Li, L Zhang, Y You… - Journal of the …, 2020 - ACS Publications
The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited
efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT …

Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy

J Li, W Ke, L Wang, M Huang, W Yin, P Zhang… - Journal of Controlled …, 2016 - Elsevier
One of distinct features in tumor tissues is the elevated concentration of reactive oxygen
species (ROS) during tumor immortality, proliferation and metastasis. However, ROS …

Fabrication of H 2 O 2-driven nanoreactors for innovative cancer treatments

Z Dong, Z Yang, Y Hao, L Feng - Nanoscale, 2019 - pubs.rsc.org
The increased production of hydrogen peroxide (H2O2) is a typical feature of cancerous
cells. This feature is closely associated with elevated oxidative stress inside solid tumour …

Recent advances in tumor microenvironment hydrogen peroxide-responsive materials for cancer photodynamic therapy

N Yang, W Xiao, X Song, W Wang, X Dong - Nano-Micro Letters, 2020 - Springer
Photodynamic therapy (PDT), as one of the noninvasive clinical cancer phototherapies,
suffers from the key drawback associated with hypoxia at the tumor microenvironment …

Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications

G Vilema-Enríquez, A Arroyo, M Grijalva… - Oxidative Medicine …, 2016 - Wiley Online Library
Lung cancer has a very high mortality‐to‐incidence ratio, representing one of the main
causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently …

O2-Supplying Nanozymes Alleviate Hypoxia and Deplete Lactate to Eliminate Tumors and Activate Antitumor Immunity

L Sun, W Gao, J Liu, J Wang, L Li, H Yu… - ACS Applied Materials …, 2022 - ACS Publications
Direct hypoxia alleviation and lactate depletion in the tumor microenvironment (TME) are
promising for effective cancer therapy but still very challenging. To address this challenge …

Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia

A Sahu, I Kwon, G Tae - Biomaterials, 2020 - Elsevier
Hypoxia, resulting from the imbalance between oxygen supply and consumption is a critical
component of the tumor microenvironment. It has a paramount impact on cancer growth …

Acidic pH and High-H2O2 Dual Tumor Microenvironment-Responsive Nanocatalytic Graphene Oxide for Cancer Selective Therapy and Recognition

B Lin, H Chen, D Liang, W Lin, X Qi… - ACS applied materials …, 2019 - ACS Publications
It is well known that tumors have an acidic pH microenvironment and contain a high content
of hydrogen peroxide (H2O2). These features of the tumor microenvironment may provide …

Biomimetic nanoplatform with H2O2 homeostasis disruption and oxidative stress amplification for enhanced chemodynamic therapy

LH Fu, XY Wu, J He, C Qi, J Lin, P Huang - Acta Biomaterialia, 2023 - Elsevier
Chemodynamic therapy (CDT) is a powerful cancer treatment strategy by producing
excessive amount of reactive oxygen species (ROS) to kill cancer cells. However, the …