Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy
Z Chu, J Yang, W Zheng, J Sun, W Wang… - Coordination Chemistry …, 2023 - Elsevier
Due to the rapid proliferation of tumors, the hydrogen peroxide (H 2 O 2) concentration of
tumor cells is higher than that of normal cells, which can be used as an effective target for …
tumor cells is higher than that of normal cells, which can be used as an effective target for …
Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy
The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited
efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT …
efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT …
Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy
J Li, W Ke, L Wang, M Huang, W Yin, P Zhang… - Journal of Controlled …, 2016 - Elsevier
One of distinct features in tumor tissues is the elevated concentration of reactive oxygen
species (ROS) during tumor immortality, proliferation and metastasis. However, ROS …
species (ROS) during tumor immortality, proliferation and metastasis. However, ROS …
Fabrication of H 2 O 2-driven nanoreactors for innovative cancer treatments
The increased production of hydrogen peroxide (H2O2) is a typical feature of cancerous
cells. This feature is closely associated with elevated oxidative stress inside solid tumour …
cells. This feature is closely associated with elevated oxidative stress inside solid tumour …
Recent advances in tumor microenvironment hydrogen peroxide-responsive materials for cancer photodynamic therapy
N Yang, W Xiao, X Song, W Wang, X Dong - Nano-Micro Letters, 2020 - Springer
Photodynamic therapy (PDT), as one of the noninvasive clinical cancer phototherapies,
suffers from the key drawback associated with hypoxia at the tumor microenvironment …
suffers from the key drawback associated with hypoxia at the tumor microenvironment …
Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications
G Vilema-Enríquez, A Arroyo, M Grijalva… - Oxidative Medicine …, 2016 - Wiley Online Library
Lung cancer has a very high mortality‐to‐incidence ratio, representing one of the main
causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently …
causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently …
O2-Supplying Nanozymes Alleviate Hypoxia and Deplete Lactate to Eliminate Tumors and Activate Antitumor Immunity
Direct hypoxia alleviation and lactate depletion in the tumor microenvironment (TME) are
promising for effective cancer therapy but still very challenging. To address this challenge …
promising for effective cancer therapy but still very challenging. To address this challenge …
Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia
Hypoxia, resulting from the imbalance between oxygen supply and consumption is a critical
component of the tumor microenvironment. It has a paramount impact on cancer growth …
component of the tumor microenvironment. It has a paramount impact on cancer growth …
Acidic pH and High-H2O2 Dual Tumor Microenvironment-Responsive Nanocatalytic Graphene Oxide for Cancer Selective Therapy and Recognition
B Lin, H Chen, D Liang, W Lin, X Qi… - ACS applied materials …, 2019 - ACS Publications
It is well known that tumors have an acidic pH microenvironment and contain a high content
of hydrogen peroxide (H2O2). These features of the tumor microenvironment may provide …
of hydrogen peroxide (H2O2). These features of the tumor microenvironment may provide …
Biomimetic nanoplatform with H2O2 homeostasis disruption and oxidative stress amplification for enhanced chemodynamic therapy
Chemodynamic therapy (CDT) is a powerful cancer treatment strategy by producing
excessive amount of reactive oxygen species (ROS) to kill cancer cells. However, the …
excessive amount of reactive oxygen species (ROS) to kill cancer cells. However, the …