Augmented renal clearance (ARC) is a phenomenon in critically ill patients characterized by
increased creatinine clearance and elimination of renally eliminated medications. Patients …

Augmented renal clearance (ARC) has been reported in approximately 30–65% of patients
in the intensive care unit (ICU) despite the presence of a normal serum creatinine …

Augmented renal clearance (ARC) is a manifestation of enhanced renal function seen in
critically ill patients. The use of regular unadjusted doses of renally eliminated drugs in …

Background Traditionally, renal function in critically ill patients has been assessed to identify
renal dysfunction, and dose adjustment is generally accepted in such a context …

Critically ill patients can display markedly abnormal physiological parameters compared
with those in ward-based or ambulatory settings. As a function of both the underlying …

The prescription of pharmaceuticals in the critically ill is complicated by a paucity of
knowledge concerning the pharmacokinetic implications of the underlying disease state …

Highlights•Augmented renal clearance (ARC) is a prevalent condition in the critically
ill.•ARC may result in sub-therapeutic exposure of renally eliminated antibiotics.•Beta …

Kidney function assessment in the critically ill overlooks the possibility for hyperfunctioning
kidneys, known as augmented renal clearance (ARC), which could contribute to therapeutic …

Objective: To describe the prevalence and natural history of augmented renal clearance in a
cohort of recently admitted critically ill patients with normal plasma creatinine concentrations …

Augmented renal clearance (ARC) refers to the state of heightened renal filtration commonly
observed in the critically ill. Its prevalence in this patient population is a consequence of the …