Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke

RO Saleh, AA Majeed, R Margiana… - Cell Biochemistry …, 2024 - Wiley Online Library
Cerebral ischemic damage is prevalent and the second highest cause of death globally
across patient populations; it is as a substantial reason of morbidity and mortality …

Ischemic brain stroke and mesenchymal stem cells: An overview of molecular mechanisms and therapeutic potential

Y Jingli, W Jing, Y Saeed - Stem Cells International, 2022 - Wiley Online Library
Ischemic brain injury is associated with a high rate of mortality and disability with no effective
therapeutic strategy. Recently, a growing number of studies are focusing on mesenchymal …

Marrow-derived mesenchymal stromal cells in the treatment of stroke

SC Cramer - Translational Neuroscience: Fundamental Approaches …, 2016 - Springer
Mesenchymal stromal cells (MSC) are a multipotent stem cell that can be derived from
several different tissues, including bone marrow. In preclinical studies, MSC have been …

[HTML][HTML] Mesenchymal stromal cells in ischemic brain injury

B Brooks, D Ebedes, A Usmani, JV Gonzales-Portillo… - Cells, 2022 - mdpi.com
Ischemic brain injury represents a major cause of death worldwide with limited treatment
options with a narrow therapeutic window. Accordingly, novel treatments that extend the …

Mesenchymal stem cells for ischemic stroke: progress and possibilities

A Lucia Maria Ferri, A Bersano, D Lisini… - Current medicinal …, 2016 - ingentaconnect.com
Stroke is the most common neurological cause of morbidity and mortality in industrialized
countries, afflicting 15 million people every year. The numbers are expected to increase …

[HTML][HTML] Mesenchymal stem cell-based therapy for stroke: current understanding and challenges

W Li, L Shi, B Hu, Y Hong, H Zhang, X Li… - Frontiers in Cellular …, 2021 - frontiersin.org
Stroke, the most prevalent cerebrovascular disease, causes serious loss of neurological
function and is the leading cause of morbidity and mortality worldwide. Despite advances in …

Mesenchymal stromal cell therapy of stroke

Y Shen, P Venkat, M Chopp, J Chen - Cellular and Molecular Approaches …, 2018 - Springer
Stroke is a major cause of high mortality, morbidity and long-term disability worldwide.
Development of neuroprotective and neurorestorative therapies for stroke has been a target …

Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress

Y Li, W Zhong, X Tang - Stem Cells International, 2021 - Wiley Online Library
Cerebral ischemia is a common global disease that is characterized by a loss of
neurological function and a poor prognosis in many patients. However, only a limited …

[HTML][HTML] Exogenous stem cells pioneer a biobridge to the advantage of host brain cells following stroke: New insights for clinical applications

MG Crowley, N Tajiri - Brain Circulation, 2017 - journals.lww.com
Stroke continues to maintain its status as one of the top causes of mortality within the United
States. Currently, the only Food and Drug Administration (FDA)-approved drug in place for …

[PDF][PDF] Stroke and mesenchymal stromal cells: mechanisms of neuroprotection and future prospects

M Dossena - J Biomol Res Ther, 2016 - pdfs.semanticscholar.org
Stroke is the second cause of morbidity and mortality worldwide [1]. The reduced blood flow
generates ischemia area due to multiple processes such as excitotoxicity, ionic imbalance …