Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal
lysine residues of core nucleosomal histones. This activity is associated generally with …

Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth
arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. One …

Histone deacetylase (HDAC) inhibitors (HDACi) cause cancer cell growth arrest and/or
apoptosis in vivo and in vitro. The HDACi suberoylanilide hydroxamic acid (SAHA) is in …

Histone deacetylase (HDACs) regulate histone acetylation by catalyzing the removal of
acetyl groups on the NH2-terminal lysine residues of the core nucleosomal histones …

This review focuses on the discovery and development of the histone deacetylase (HDAC)
inhibitor, suberoylanilide hydroxamic acid (SAHA). Post-translational modifications of the …

Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential
anticancer agents for the treatment of solid and hematological malignancies. In recent years …

Histone deacetylase inhibitor‐induced expression of p21WAF1 is p53 independent. In the
present study, we provide evidence that trichostatin A (TSA), a specific inhibitor of histone …

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

Aberrant gene regulation plays an important role in tumor initiation and progression, and the
acetylation of histones is a well understood key component of gene regulation. Histone …

Suberoylanilide hydroxamic acid (SAHA) is a potent inhibitor of histone deacetylases
(HDACs) that causes growth arrest, differentiation, and/or apoptosis of many tumor types in …