In silico screening of compounds from the Bahia semiarid region for identification of potential inhibitors of the p38 MAPK protein
IV Santana, AB Côrtes Filho, AAF Pinheiro… - Research, Society and …, 2020 - rsdjournal.org
The P38 MAPK protein is mainly involved in the synthesis of the proinflammatory cytokines
IL1 and TNF-alpha and is important in the maintenance and amplification of the …
IL1 and TNF-alpha and is important in the maintenance and amplification of the …
Virtual screening based on pharmacophore model followed by docking simulation studies in search of potential inhibitors for p38 map kinase
M Shahlaei, E Doosti - Biomedicine & Pharmacotherapy, 2016 - Elsevier
P38 mitogen-activated protein (MAP) kinase inhibitors are closely involved in the production
of inflammatory cytokines. These compounds are considered promising therapeutic agents …
of inflammatory cytokines. These compounds are considered promising therapeutic agents …
In silico screening and in vitro activity measurement of javamide analogues as potential p38 MAPK inhibitors
JB Park - International Journal of Molecular Sciences, 2017 - mdpi.com
p38 Mitogen-activated protein kinase (p38 MAPK) is a protein kinase critically involved in
the progress of inflammation/stress-associated diseases. Our data suggested that javamide …
the progress of inflammation/stress-associated diseases. Our data suggested that javamide …
Evaluation of the combination mode and features of p38 MAPK inhibitors: construction of different pharmacophore models and molecular docking
B Sun, H Zhang, Y Dong, L Zhao, J Han… - Molecular Simulation, 2019 - Taylor & Francis
Abnormal expression of tumour necrosis factor-α (TNF-α) can lead to various pathological
reactions, such as arthritis, psoriasis, krone disease, etc. p38 mitogen-activated protein …
reactions, such as arthritis, psoriasis, krone disease, etc. p38 mitogen-activated protein …
Docking Sites of Indole Derivative on Mitogen-Activated Protein Kinase (MAPK) Inhibitor (PDB ID-1A9U) against Inflammation.
RJ Bhor, AC Agale, GM Sitaram… - International …, 2024 - search.ebscohost.com
Background: The serine/threonine kinase p38 Mitogen-Activated Protein (MAP) kinase is
one of the most well studied kinases in the inflammatory process. The goal of this study was …
one of the most well studied kinases in the inflammatory process. The goal of this study was …
Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors
R de Oliveira Lopes, NC Romeiro, CKF de Lima… - European journal of …, 2012 - Elsevier
p38 mitogen-activated protein kinase (p38 MAPK) is an important signal transducing
enzyme involved in many cellular regulations, including signaling pathways, pain and …
enzyme involved in many cellular regulations, including signaling pathways, pain and …
Ligand-based 3D pharmacophore design, virtual screening and molecular docking for novel p38 MAPK inhibitors
L He, R Dai, XR Zhang, SY Gao, YY He… - Medicinal Chemistry …, 2015 - Springer
The p38 mitogen-activated protein kinase (MAPK) identified in human monocytes represents
a potentially attractive therapeutic target for a class of cytokine suppressive anti …
a potentially attractive therapeutic target for a class of cytokine suppressive anti …
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation
A Astolfi, M Kudolo, J Brea, G Manni, G Manfroni… - European Journal of …, 2019 - Elsevier
This work describes the rational discovery of novel chemotypes of p38α MAPK inhibitors
using a funnel approach consisting of several computer-aided drug discovery methods and …
using a funnel approach consisting of several computer-aided drug discovery methods and …
Computer-aided drug design applied to a series of pyridinyl imidazole derivatives targeting p38α MAP kinase: 2D-QSAR, docking, MD simulation, and ADMET …
A El Aissouq, A Lachhab, S El Rhabori… - New Journal of …, 2022 - pubs.rsc.org
The p38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic
inflammation. Here, 2D-QSAR and molecular docking studies were performed on a new …
inflammation. Here, 2D-QSAR and molecular docking studies were performed on a new …
Identification of p38α MAP kinase inhibitors by pharmacophore based virtual screening
The p38α mitogen-activated protein (MAP) kinase plays a vital role in treating many
inflammatory diseases. In the present study, a combined ligand and structure based …
inflammatory diseases. In the present study, a combined ligand and structure based …