Neuronal signaling in the central nervous system (CNS) associates with release of K+ into
the extracellular space resulting in transient increases in [K+] o. This elevated K+ is swiftly …

An important feature of neuronal signalling is the increased concentration of K+ in the
extracellular space. The K+ concentration is restored to its original basal level primarily by …

Network activity in the brain is associated with a transient increase in extracellular K+
concentration. The excess K+ is removed from the extracellular space by mechanisms …

Neuronal activity results in release of K+ into the extracellular space of the central nervous
system. If the excess K+ is allowed to accumulate, neuronal firing will be compromised by …

During neuronal activity in the brain, extracellular K+ rises and is subsequently removed to
prevent a widespread depolarization. One of the key players in regulating extracellular K+ is …

Initial clearance of extracellular K+([K+] o) following neuronal excitation occurs by astrocytic
uptake, because elevated [K+] o activates astrocytic but not neuronal Na+, K+-ATPases …

This paper describes the roles of the astrocytic Na+, K+-ATPase for K+ homeostasis in brain.
After neuronal excitation it alone mediates initial cellular re-accumulation of moderately …

Neuronal excitation increases extracellular K+ concentration ([K+] o) in vivo and in
incubated brain tissue by stimulation of postsynaptic glutamatergic receptors and by channel …

The Kir4. 1 channel is crucial for the maintenance of the resting membrane potential of glial
cells, and it is believed to play a main role in the homeostasis of extracellular potassium. To …

The importance of astrocytic K+ uptake for extracellular K+([K+] e) clearance during
neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It …