The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

Numerous antimicrobial drugs have been developed and commercialized to kill and inhibit
the growth of pathogenic microbes. The therapeutic efficiency of these drugs has however …

Background: Emerging resistance of bacterial pathogens to clinically used drugs, including
not only first-choice but also second-and third-choice drugs, is alarming, but since the 1990s …

Highlights•Computational tools for the guided design of novel antibiotics.•The importance of
biological descriptors and computational biology for the development of enhanced …

Prolonged antibiotic therapy for the bacterial infections has resulted in high levels of
antibiotic resistance. Initially, bacteria are susceptible to the antibiotics, but can gradually …

The inappropriate use of antibiotics and an inadequate control of infections have led to the
emergence of resistant strains which represent a major threat to public health and the global …

Recently, several new drugs for the treatment of bacterial infections have been developed.
Quinupristin/dalfopristin, moxifloxacin and gatifloxacin have been approved throughout the …

Pathogenic antibiotic resistant bacteria pose one of the most important health challenges of
the 21st century. The overuse and abuse of antibiotics coupled with the natural evolutionary …

Bacterial resistance to commonly used antibiotics is constantly increasing. Bacteria
particularly dangerous for human life are methicillin-resistant Staphylococcus aureus …

The discovery and development of antibacterial drugs in the twentieth century were major
scientific and medical achievements that have had profound benefits for human society …