Damage to the zebrafish retina stimulates resident Müller glia to reprogram, reenter the cell
cycle, divide asymmetrically, and produce neuronal progenitor cells that amplify and …

Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce
neuronal progenitor cells that proliferate and differentiate into retinal neurons. Notch …

Retinal damage in teleosts, unlike mammals, induces robust Müller glia-mediated
regeneration of lost neurons. We examined whether Notch signaling regulates Müller glia …

Zebrafish Müller glia (MG) respond to retinal injury by suppressing Notch signaling and
producing progenitors for retinal repair. A certain threshold of injury‐derived signal must be …

Previous studies have indicated that Müller glia in chick and fish retinas can re-enter the cell
cycle, express progenitor genes, and regenerate neurons via the Notch signaling pathway in …

Photoreceptor degeneration leads to irreversible vision loss in humans with retinal
dystrophies such as retinitis pigmentosa. Whereas photoreceptor loss is permanent in …

The chicken retina is capable of limited regeneration. In response to injury, some Müller glia
proliferate and de-differentiate into progenitor cells. However, most of these progenitors fail …

Müller glial (MG) cells in the zebrafish retina respond to injury by acquiring retinal stem-cell
characteristics. Thousands of gene expression changes are associated with this event. Key …

Fish can regenerate retinal neurons following ocular injury. Evidence is mounting that
astrocytic glia function as inducible, regenerative stem cells in this process, but the …

Notch–Delta signaling has been implicated in several alternative modes of function in the
vertebrate retina. To further investigate these functions, we examined retinas from zebrafish …