Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate
biologic mechanisms inherent in the normal cell state that have been co-opted to drive the …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

Evolutionary theories are critical for understanding cancer development at the level of
species as well as at the level of cells and tissues, and for developing effective therapies …

Cancer progression is an evolutionary process. During this process, evolving cancer cell
populations encounter restrictive ecological niches within the body, such as the primary …

Our understanding of cancer is being transformed by exploring clonal diversity, drug
resistance, and causation within an evolutionary framework. The therapeutic resilience of …

The cancer stem cell hypothesis is an evolving concept of oncogenesis that has recently
gained wide acceptance. In its simplest form this hypothesis suggests that many if not all …

While standard therapies can lead to an initial remission of aggressive cancers, they are
often only a transient solution. The resistance and relapse that follows is driven by tumor …