Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease

A Mitrofanova, S Merscher, A Fornoni - Nature Reviews Nephrology, 2023 - nature.com
Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

J Baek, C He, F Afshinnia, G Michailidis… - Nature Reviews …, 2022 - nature.com
Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease

K Stadler, IJ Goldberg, K Susztak - Current diabetes reports, 2015 - Springer
Although diabetes is mainly diagnosed based on elevated glucose levels, dyslipidemia is
also observed in these patients. Chronic kidney disease (CKD), a frequent occurrence in …

Systemic and renal lipids in kidney disease development and progression

P Wahl, GM Ducasa, A Fornoni - American Journal of …, 2016 - journals.physiology.org
Altered lipid metabolism characterizes proteinuria and chronic kidney diseases. While it is
thought that dyslipidemia is a consequence of kidney disease, a large body of clinical and …

Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations

H Noels, M Lehrke, R Vanholder… - Nature Reviews …, 2021 - nature.com
Chronic kidney disease (CKD) induces modifications in lipid and lipoprotein metabolism and
homeostasis. These modifications can promote, modulate and/or accelerate CKD and …

Renal lipid metabolism and lipotoxicity

IA Bobulescu - Current opinion in nephrology and hypertension, 2010 - journals.lww.com
Current knowledge on renal lipid physiology and pathophysiology is insufficient, but
provides a strong foundation and incentive for further exploration. The future holds …

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

M Herman-Edelstein, P Scherzer, A Tobar, M Levi… - Journal of lipid …, 2014 - ASBMB
Animal models link ectopic lipid accumulation to renal dysfunction, but whether this process
occurs in the human kidney is uncertain. To this end, we investigated whether altered renal …

[HTML][HTML] New insights into renal lipid dysmetabolism in diabetic kidney disease

A Mitrofanova, G Burke, S Merscher… - World journal of …, 2021 - ncbi.nlm.nih.gov
Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by
dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs …

Lipid nephrotoxicity: new concept for an old disease

L Gyebi, Z Soltani, E Reisin - Current hypertension reports, 2012 - Springer
The prevalence of obesity in the United States remains high, exceeding 30% in most states.
As this trend continues unhindered, we will continue see a persistent rise in obesity-related …

Lipid accumulation and chronic kidney disease

Z Gai, T Wang, M Visentin, GA Kullak-Ublick, X Fu… - Nutrients, 2019 - mdpi.com
Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …