Luteolin Protects Against Obese Sarcopenia in Mice with High‐Fat Diet‐Induced Obesity by Ameliorating Inflammation and Protein Degradation in Muscles

JW Kim, SK Shin, EY Kwon - Molecular Nutrition & Food …, 2023 - Wiley Online Library
Scope Although sarcopenia is mainly caused by aging, sarcopenia due to obesity has
become an emerging issue given the increase in obesity among people of various ages …

Luteolin targets the toll-like receptor signaling pathway in prevention of hepatic and adipocyte fibrosis and insulin resistance in diet-induced obese mice

EY Kwon, MS Choi - Nutrients, 2018 - mdpi.com
This study was to investigate the protective role of luteolin on inflammation-mediated
metabolic diseases, focusing on the role of luteolin in the modulation of the Toll-like receptor …

Low‐dose diet supplement of a natural flavonoid, luteolin, ameliorates diet‐induced obesity and insulin resistance in mice

N Xu, L Zhang, J Dong, X Zhang… - Molecular nutrition & …, 2014 - Wiley Online Library
Scope Mast cells play important roles in diet‐induced obesity and diabetes, and some
synthetic mast cell stabilizers can improve related metabolic disturbances in mice. Luteolin …

Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity

EY Kwon, UJ Jung, T Park, JW Yun, MS Choi - Diabetes, 2015 - Am Diabetes Assoc
The flavonoid luteolin has various pharmacological activities. However, few studies exist on
the in vivo mechanism underlying the actions of luteolin in hepatic steatosis and obesity. The …

Lutein ameliorates high‐fat diet‐induced obesity, fatty liver, and glucose intolerance in C57BL/6J mice

SS Gopal, SV Sukhdeo, B Vallikannan… - Phytotherapy …, 2023 - Wiley Online Library
Obesity is a multi‐factorial metabolic syndrome that increases the risk of cardiovascular
diseases, diabetes, and cancer. We recently demonstrated the antiadipogenic efficacy of …

Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages

L Zhang, YJ Han, X Zhang, X Wang, B Bao, W Qu, J Liu - Diabetologia, 2016 - Springer
Aims/hypothesis Inflammatory polarisation of adipose tissue macrophages (ATMs) plays a
critical role in the development of obesity-associated metabolic diseases such as insulin …

Luteolin reduces adipose tissue macrophage inflammation and insulin resistance in postmenopausal obese mice

Y Baek, MN Lee, D Wu, M Pae - The Journal of nutritional biochemistry, 2019 - Elsevier
Previously, we showed that loss of ovarian function in mice fed high-fat diet exacerbated
insulin resistance and adipose tissue inflammation. In the current study, we tested whether …

Luteolin prevents cardiometabolic alterations and vascular dysfunction in mice with HFD-induced obesity

D Gentile, M Fornai, C Pellegrini, R Colucci… - Frontiers in …, 2018 - frontiersin.org
Purpose: Luteolin exerts beneficial effects against obesity-associated comorbidities,
although its influence on vascular dysfunction remains undetermined. We examined the …

Luteolin enhances insulin sensitivity via activation of PPARγ transcriptional activity in adipocytes

L Ding, D Jin, X Chen - The Journal of nutritional biochemistry, 2010 - Elsevier
Obesity and insulin resistance have been linked to a low-grade chronic inflammatory
response characterized by increased macrophage infiltration, altered cytokine production …

Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues

Z Zhang, J Wang, Y Lin, J Chen, J Liu… - Critical Reviews in Food …, 2024 - Taylor & Francis
Obesity is characterized by excessive body fat accumulation and is a high-risk factor for
metabolic comorbidities, including type 2 diabetes, nonalcoholic fatty liver disease, and …