Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion

ZR Zhang, YN Zhang, HQ Zhang… - PLoS neglected …, 2022 - journals.plos.org
COVID-19 caused by SARS-CoV-2 has posed a significant threat to global public health
since its outbreak in late 2019. Although there are a few drugs approved for clinical …

Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion

C Yang, C Cheng, J Wang, K Chen, J Zhan… - … Fang yi ke da xue xue …, 2021 - europepmc.org
Objective The investigate the inhibitory effects of the traditional Chinese medicine (TCM)
monomer salvianolic acid B (Sal-B) and its magnesium salt Salvia Miltiorrhiza …

Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

L Huang, TTT Yuen, Z Ye, S Liu, G Zhang… - … and Targeted Therapy, 2021 - nature.com
Middle East respiratory syndrome-related coronavirus (MERS-CoV) is the pathogen
responsible for the outbreak of MERS, and we are currently being affected by coronavirus …

[HTML][HTML] Exploring the efficacy of naturally occurring biflavone based antioxidants towards the inhibition of the SARS-CoV-2 spike glycoprotein mediated membrane …

S Mondal, A Karmakar, T Mallick, NA Begum - Virology, 2021 - Elsevier
Molecular docking studies were done to show the inhibitory effect of two naturally occurring
biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 …

Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity

Y Zhu, D Yu, H Yan, H Chong, Y He - Journal of virology, 2020 - Am Soc Microbiol
ABSTRACT The 2019 coronavirus disease (COVID-19), caused by the emerging severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed serious threats to …

Drug repurposing of itraconazole and estradiol benzoate against COVID‐19 by blocking SARS‐CoV‐2 spike protein‐mediated membrane fusion

C Yang, X Pan, Y Huang, C Cheng, X Xu… - Advanced …, 2021 - Wiley Online Library
SARS‐CoV‐2 caused the emerging epidemic of coronavirus disease in 2019 (COVID‐19).
To date, there are more than 82.9 million confirmed cases worldwide, there is no clinically …

Mulberry component kuwanon C exerts potent therapeutic efficacy in vitro against COVID-19 by blocking the SARS-CoV-2 spike S1 RBD: ACE2 receptor interaction

YS Kim, EB Kwon, B Kim, HS Chung, G Choi… - International Journal of …, 2022 - mdpi.com
There has been an immense effort by global pharmaceutical companies to develop anti-
COVID-19 drugs, including small molecule-based RNA replication inhibitors via drug …

Phenothiazines inhibit SARS-CoV-2 entry through targeting spike protein

T Liang, S Xiao, Z Wu, X Lv, S Liu, M Hu, G Li, P Li… - Viruses, 2023 - mdpi.com
Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public …

Clinical antiviral drug arbidol inhibits infection by SARS-CoV-2 and variants through direct binding to the spike protein

A Shuster, D Pechalrieu, CB Jackson… - ACS Chemical …, 2021 - ACS Publications
Arbidol (ARB) is a broad-spectrum antiviral drug approved in Russia and China for the
treatment of influenza. ARB was tested in patients as a drug candidate for the treatment at …

Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formation

TY Kim, JY Kim, HC Kwon, S Jeon, S ji Lee, H Jung… - Antiviral Research, 2022 - Elsevier
The continuous emergence of SARS-CoV-2 variants prolongs COVID-19 pandemic.
Although SARS-CoV-2 vaccines and therapeutics are currently available, there is still a …