Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

Replicative capacity of somatic cells is limited. It indicates that aging also develops at the
cellular level, and this is described as “cellular senescence”. Senescent cells become …

Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Cellular senescence within the cardiovascular system has, until recently, been understudied
and unappreciated as a factor in the development of age‐related cardiovascular diseases …

Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular
matrix and orchestrates a damage response to maintain cardiac architecture and …

Cardiovascular disease (CVD) is the most common disease to increase as life expectancy
increases. Most high-profile pharmacological treatments for age-related CVD have led to …

Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the cause of death in 40% of individuals over 65 years old. Ageing is …

Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …