Conditions that partially inhibit DNA replication induce expression of common fragile sites.
These sites form gaps and breaks on metaphase chromosomes and are deleted and …

Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks
on metaphase chromosomes following conditions of partial replication stress. Fragile sites …

Common fragile sites are specific regions of the genome that form gaps and breaks on
metaphase chromosomes when DNA synthesis is partially inhibited. Fragile sites and their …

Common fragile sites are loci that form chromosome gaps or breaks when DNA synthesis is
partially inhibited. Fragile sites are prone to deletions, translocations, and other …

Aphidicolin-induced common fragile sites are site-specific gaps or breaks seen on
metaphase chromosomes after partial inhibition of DNA synthesis. These fragile sites were …

Common fragile sites are large chromosomal regions that preferentially exhibit gaps or
breaks after DNA synthesis is partially perturbed. Fragile site instability in cultured cells is …

Perturbed DNA replication in early stages of cancer development induces chromosomal
instability preferentially at fragile sites. However, the molecular basis for this instability is …

Common fragile sites are regions showing site-specific gaps and breaks on metaphase
chromosomes after partial inhibition of DNA synthesis. Common fragile sites are normally …

Breaks at common fragile sites (CFS) are a recognized source of genome instability in pre-
neoplastic lesions, but how such checkpoint-proficient cells escape surveillance and …

Common fragile sites have been involved in neoplastic transformation, although their
molecular basis is still poorly understood. Here, we demonstrate that inhibition of the SMC1 …