Bladder cancer (BCa) is the most common malignant disease of the urinary tract system, yet
the etiology is still poorly understood. Clinically, the majority of BCa patients progress to …

Abstract CXC chemokine ligand 12 (CXCL12) is an important member of the CXC subfamily
of chemokines, and has been extensively studied in various human body organs and …

Bladder cancer is one of the most common tumors of the genitourinary tract; however, the
molecular events underlying growth and invasion of the tumor remain unclear. Here, role of …

CXCL12/CXCR4 signaling plays important roles in tumor cell metastasis in many types of
cancers, and CXCR4 is the key regulator of cell motility in bladder cancer. Emerging …

Objective The interplay between chemokine CXC motif ligand 12 (CXCL12) and its specific
receptors is known to trigger various signaling pathways, contributing to tumor proliferation …

The interactions between chemokines and their receptors are closely involved in the
progression and metastasis of cancer. We hypothesized that the CXCL16-CXCR6 ligand …

Abstract BACKGROUND: C‐X‐C chemokine receptor 4 (CXCR4) and CXCR7 are 7‐
transmembrane chemokine receptors of the stroma‐derived factor (SDF‐1). CXCR4, but not …

Chemokine CXC motif ligand 5 (CXCL5) is critical for bladder cancer growth and
progression. Our previous study demonstrated that increase of CXCL5 in bladder cancer cell …

Purpose CXCL3 and its receptor CXCR2 were considered to play particularly important
roles in the progression of malignancies. However, the investigations about CXCL3/CXCR2 …

Tumour-associated macrophages (TAMs) are associated with both the progression and poor
prognosis of a variety of solid tumours. This study aimed to investigate and clarify the tumour …