Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

Cancer is a multifaceted and complex pathology characterized by uncontrolled cell
proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory …

Matrix metalloproteinases (MMPs) or matrixins, are members of a zinc-dependent
endopeptidase family. They cause remodeling of the extracellular matrix (ECM) leading to …

The extracellular matrix (ECM) provides a physical framework for the cells and functions as a
gel medium. Remodeling of the ECM is crucial during physiological cell migration …

The extracellular matrix (ECM) is a complex network of extracellular-secreted
macromolecules, such as collagen, enzymes and glycoproteins, whose main functions deal …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Matrix metalloproteinases (MMPs) are a family of more than 28 enzymes that were initially
identified on the basis of their ability to cleave most elements of the extracellular matrix …

Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …

The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix remodeling proteases whose activity has been implicated in a number of …