Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions
Translating a set of disease regions into insight about pathogenic mechanisms requires not
only the ability to identify the key disease genes within them, but also the biological …
only the ability to identify the key disease genes within them, but also the biological …
Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function
Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases,
such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes …
such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes …
Boosting the power of schizophrenia genetics by leveraging new statistical tools
OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …
associated with schizophrenia, but these variants explain only a small portion of the …
A genome-wide investigation of SNPs and CNVs in schizophrenia
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy
number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and …
number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and …
Transcriptome study of differential expression in schizophrenia
AR Sanders, HHH Göring, J Duan… - Human molecular …, 2013 - academic.oup.com
Schizophrenia genome-wide association studies (GWAS) have identified common SNPs,
rare copy number variants (CNVs) and a large polygenic contribution to illness risk, but …
rare copy number variants (CNVs) and a large polygenic contribution to illness risk, but …
Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia
MJ Owen, N Craddock… - Archives of general …, 2010 - jamanetwork.com
This article reviews recent genome-wide association studies (GWAS) of schizophrenia and
considers future research directions. Until recently, genome-wide scans for dis-ease risk …
considers future research directions. Until recently, genome-wide scans for dis-ease risk …
[PDF][PDF] Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
Several lines of evidence suggest that genome-wide association studies (GWASs) have the
potential to explain more of the" missing heritability" of common complex phenotypes …
potential to explain more of the" missing heritability" of common complex phenotypes …
Linking disease associations with regulatory information in the human genome
Genome-wide association studies have been successful in identifying single nucleotide
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Genome-wide association studies (GWAS) have identified more than 100 schizophrenia
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …
Genome-wide association studies of schizophrenia: does bigger lead to better results?
SE Bergen, TL Petryshen - Current opinion in psychiatry, 2012 - journals.lww.com
Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …
mechanisms leading to manifestation of the disease. New and more effective treatments for …